Custom Peptides
Cayman Chemical NKH477hydrochlorIde 10mg
A water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously; stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms; relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM
Cayman Chemical Lonca fulvotomntosa adn 10mg
A triterpenoid saponin with diverse biological activities; increases spontaneous motoric activity in isolated rat stomach corpus and fundus strips from 25 to 320 μM; cytotoxic to J82, T24, Colon26, and 3LL Lewis cells (EC50s = 15.5, 16.5, 12.5, and 1.1 μM, respectively); increases survival time in a 3LL Lewis mouse lung carcinoma model at 7.5 and 15 mg/kg; reduces acetic acid-induced writhing in mice at 10 and 20 mg/kg; reduces paw edema in a rat model of rheumatoid arthritis induced by FCA; prevents carbon tetrachloride-induced increases in serum ALT and LDH activity as well as hepatic levels of MDA in a mouse model of hepatic injury; decreases levels of CYP2E1 in mouse liver
Cayman Chemical ParItaprevIr 10mg
An orally bioavailable, direct-acting inhibitor of HCV NS3/4A serine protease; inhibits HCV replication in stable Huh7-derived replicon cell lines infected with subgenomic genotypes 1a, 1b, 2a, 3a, 4a, and 6a (EC50s = 1, 0.21, 5.3, 19, 0.09, and 0.69 nM, respectively); inhibits replicons from clinical isolates of genotypes 1a (EC50s = 0.43 to 1.87 nM) and 1b (EC50s = 0.033 to 0.087 nM)
Cayman Chemical SematIlIdehydrochlorIde 10mg
A class III antiarrhythmic agent; prolongs electrically stimulated APD and increases ERP in isolated guinea pig left atria; decreases spontaneous sinoatrial beating rates and induces ERP prolongation of the atrioventricular node in isolated perfused canine hearts; increases ERP, prolonging cardiac refractoriness, in situ in open-chest dog hearts at 1 mg/kg; inhibits PES-induced arrhythmias in dogs
Cayman Chemical GInkgolIde B 10mg
A potent PAFR antagonist that inhibits platelet aggregation at concentrations from 10-500 μM; demonstrates anticancer, anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects
Cayman Chemical FMF-04-159-2 10mg
A TAIRE family kinase inhibitor; binds to Cdk14 and Cdk16 (IC50s = 88 and 10.1 nM, respectively); selectively inhibits Cdk14, Cdk16, Cdk17, and Cdk18 over a panel of 16 additional kinases at 1 µM but does inhibit Cdk2 and Cdk10 by greater than 70% at 1 µM
Cayman Chemical MadecasosIde 10mg
A natural triterpenoid with a wide range of reported anti-inflammatory, wound healing, and antioxidant activities; suppresses LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity
Cayman Chemical 1 3DIpalmItol2EIcosapenta 10mg
A triacylglycerol; dietary administration decreases hepatic triacylglycerol levels in mice
Cayman Chemical MIsoprostolfree acId 10mg
Misoprostol is a prostaglandin E1 (Item No. 13010) analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 UG/kg),{1754} inhibit superoxide generation in human neutrophils (EC50 = 0.35 µM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; Item No. 10006317) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.{2313}
Cayman Chemical ML-241hydrochlorIde 10mg
A selective inhibitor of p97 (IC50 = 0.11 µM); selective for the p97 D2 domain; disrupts the ERAD pathway, preventing the degradation of p97-dependent proteasome substrates in a reporter assay using HeLa cells (IC50 = 3.5 µM) and inducing the accumulation of ubiquitin conjugates in the nuclear plus membrane and cytosolic compartments of SW403 cells at 5 and 10 µM
Cayman Chemical 2-MAPBhydrochlorIde 10mg
An analytical reference standard categorized as a benzofuran; has been associated with fatal overdoses; intended for research and forensic applications
Cayman Chemical MIldronatehydrate 10mg
A structural analog of γBB that inhibits γBB hydroxylase (IC50 = 62 µM) and carnitine acetyltransferase (Ki = 1.6 mM); has cardioprotective and neuroprotective effects; improves cognition and reduces amyloid-β pathology in a mouse model of Alzheimer’s disease
Cayman Chemical Ro 106-9920 10mg
A small molecule inhibitor of NF-κB-dependent expression of TNF-α, IL-1β, and IL-6 (IC50 50 = 2.3 µM)
Cayman Chemical Esmolol AcIdhydrochlorIde 10mg
An active metabolite of esmolol; inhibits isoproterenol-induced increases in the beating rate of isolated guinea pig right atria (pA2 = 3.73); prevents isoproterenol-induced tachycardia and hypotension in anesthetized dogs; a potential impurity in commercial preparations of esmolol
Cayman Chemical 1Oleoyl2LInoleoylracglyc 10mg
A diacylglycerol; has been found in raw and dry-cured Iberian ham